Fast, Volumetric Imaging with Microscopes
3 Forbes Road
Lexington
MA
Photonics Society
Please Join us on Thursday, January 9th, for the third talk of the 2019-2020 IEEE Photonics Society Boston Chapter’s Lecture Series.
Prof. Jerome Mertz of Boston University will talk about fast, large-scale microscope imaging. We hope you can make it.
We will have pizza dinner prior to the talk. Dinner and networking start at 6:30pm. Talk begins at 7:00pm. Located at MIT Lincoln Labs, 3 Forbes Road in Lexington, MA.
Fast, volumetric imaging over large scales has been a long-standing challenge in biological microscopy. Camera-based microscopes are typically hampered by the problem of out-of-focus background which undermines image contrast. This background must be reduced, or eliminated, to achieve volumetric imaging. Alternatively, scanning techniques such as confocal and multiphoton microscopy can provide high contrast and high speed, but their generalization to volumetric imaging requires an axial scanning mechanism, which, in general, drastically reduces speed. I will describe a variety of strategies we have developed to enable fast, high-contrast, volumetric imaging over large length scales. These strategies include targeted-illumination widefield microscopy, multi-z confocal microscopy and reverberation multiphoton microscopy. I will discuss the principles of these strategies and present experimental validations.
Biography: Jerome Mertz received an AB in physics from Princeton University in 1984, and a PhD in quantum optics from UC Santa Barbara and the University of Paris VI in 1991. Following postdoctoral studies at the University of Konstanz and at Cornell University, he became a CNRS research director at the Ecole Supérieure de Physique et de Chimie Industrielle in Paris. He is currently a professor of Biomedical Engineering at Boston University. His interests are in the development and applications of novel optical microscopy techniques for biological imaging. He is also author of a textbook entitled Introduction to Optical Microscopy, 2nd ed.